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Search Results for " Ubiquitin ligase "

ターゲット

155

阻害剤

天然化合物

141

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T9809	E3 ligase Ligand 23		Ligand for E3 Ligase
	E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.		Ligand for E3 Ligase
T23371	SMER3	SMER 3	Others , Ligand for E3 Ligase
	SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune respon...		Others , Ligand for E3 Ligase
T8564	BC-1382		Others , E1/E2/E3 Enzyme
	BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).		Others , E1/E2/E3 Enzyme
T24136	Heclin		E1/E2/E3 Enzyme
	Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.		E1/E2/E3 Enzyme
T18064	Lenalidomide-Br		Ligand for E3 Ligase
	Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a...		Ligand for E3 Ligase
T3549	Avadomide	CC 122	Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
	Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.		Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
T16102	ML-792		E1/E2/E3 Enzyme
	ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...		E1/E2/E3 Enzyme
T5199	COH000		E1/E2/E3 Enzyme
	COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).		E1/E2/E3 Enzyme
T16699	PYZD-4409		Others , E1/E2/E3 Enzyme
	PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.		Others , E1/E2/E3 Enzyme
T12261	NSC232003		E1/E2/E3 Enzyme
	NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.		E1/E2/E3 Enzyme
T16901	SMIP004		Apoptosis , Others , E1/E2/E3 Enzyme
	SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.		Apoptosis , Others , E1/E2/E3 Enzyme
T5374	NAcM-OPT		E1/E2/E3 Enzyme , NEDD8
	NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).		E1/E2/E3 Enzyme , NEDD8
T7415	DKM 2-93		E1/E2/E3 Enzyme
	DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).		E1/E2/E3 Enzyme
T2158	Nutlin-3	Nutlin3	E1/E2/E3 Enzyme
	Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.		E1/E2/E3 Enzyme
T3517	RO8994		Mdm2 , E1/E2/E3 Enzyme , p53
	RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).		Mdm2 , E1/E2/E3 Enzyme , p53
T16888	SJ-172550		Mdm2 , E1/E2/E3 Enzyme
	SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).		Mdm2 , E1/E2/E3 Enzyme
T8428	Subasumstat	TAK-981	E1/E2/E3 Enzyme
	Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.		E1/E2/E3 Enzyme
T7379	2-D08		E1/E2/E3 Enzyme , TAM Receptor
	2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.		E1/E2/E3 Enzyme , TAM Receptor
T6629	PYR-41	PYR41,PYR 41	Apoptosis , E1/E2/E3 Enzyme
	PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.		Apoptosis , E1/E2/E3 Enzyme
T3653	MX69		Mdm2 , E1/E2/E3 Enzyme , IAP
	MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.		Mdm2 , E1/E2/E3 Enzyme , IAP
T6149	YH239-EE		Apoptosis , E1/E2/E3 Enzyme
	YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.		Apoptosis , E1/E2/E3 Enzyme
T9236	WSB1 Degrader 1		Others , E1/E2/E3 Enzyme
	WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.		Others , E1/E2/E3 Enzyme
T13244	Ubiquitination-IN-1		Others
			Others
T3317	SZL P1-41		Apoptosis , Others , E1/E2/E3 Enzyme
	SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...		Apoptosis , Others , E1/E2/E3 Enzyme
T11980	MD-224		Mdm2 , E1/E2/E3 Enzyme , PROTACs
	MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.		Mdm2 , E1/E2/E3 Enzyme , PROTACs
T7889	C25-140		Others , TNF , E1/E2/E3 Enzyme , NF-κB
	C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.		Others , TNF , E1/E2/E3 Enzyme , NF-κB
T10703	Mezigdomide	CC-92480	Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
	Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.		Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
T13349	WS-383		E1/E2/E3 Enzyme
	WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).		E1/E2/E3 Enzyme
T4253	Skp2 Inhibitor C1	SKPin C1	Others , E1/E2/E3 Enzyme
	Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.		Others , E1/E2/E3 Enzyme
T3110	PRT4165	NSC600157,PRT 4165	BMI-1 , Others , E1/E2/E3 Enzyme
	PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.		BMI-1 , Others , E1/E2/E3 Enzyme
T5555	Siremadlin	NVP-HDM 201	E1/E2/E3 Enzyme
	Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.		E1/E2/E3 Enzyme
T6254	Idasanutlin	RG7388,Ro 5503781	Mdm2 , E1/E2/E3 Enzyme
	Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).		Mdm2 , E1/E2/E3 Enzyme
T6965	RG7112	RG-7112,RG 7112,RO5045337	Mdm2 , E1/E2/E3 Enzyme
	RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.		Mdm2 , E1/E2/E3 Enzyme
T16974	TAK-243	MLN7243	Apoptosis , E1/E2/E3 Enzyme , NF-κB
	TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh...		Apoptosis , E1/E2/E3 Enzyme , NF-κB
T1493	BH3I-1	BHI1	BCL , E1/E2/E3 Enzyme
	BH3I-1 (BHI1) is a Bcl-2 antagonist.		BCL , E1/E2/E3 Enzyme
TQ0231	NVP-CGM097	CGM097	Mdm2 , E1/E2/E3 Enzyme
	NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).		Mdm2 , E1/E2/E3 Enzyme
TQ0127	Navtemadlin	AMG232,CS-1300	Mdm2 , E1/E2/E3 Enzyme
	Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.		Mdm2 , E1/E2/E3 Enzyme
T6611	NSC697923	2-[(4-methylphenyl)sulfonyl]-5-nitrofuran	E1/E2/E3 Enzyme
	NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct me...		E1/E2/E3 Enzyme
T2243	Serdemetan	JNJ-26854165	Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
	Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.		Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
T6023	Nutlin-3a	(-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3	Apoptosis , E1/E2/E3 Enzyme , Autophagy
	Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.		Apoptosis , E1/E2/E3 Enzyme , Autophagy
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T6585	SAR405838	MI773,MI 773,MI-77301,MI-773	Mdm2 , E1/E2/E3 Enzyme
	MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.		Mdm2 , E1/E2/E3 Enzyme
T8929	BC1618	2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-	Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
	BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and imp...		Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
T12186	Navitoclax-piperazine	ABT-263-piperazine	BCL , Ligands for Target Protein for PROTAC
	Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).		BCL , Ligands for Target Protein for PROTAC
T6614	Nutlin-3b	(+)-Nutlin-3	Mdm2 , E1/E2/E3 Enzyme
	Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.		Mdm2 , E1/E2/E3 Enzyme
T31221	DBRD9	dBRD-9,dBRD 9	PROTACs
	dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin li...		PROTACs
T60078	NSC2805	2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol	Others
	NSC2805 is an inhibitor of WWP2, an E3 ubiquitin ligase with an IC50 of 0.38 μM. NSC2805 can be used in anticancer studies.		Others
T17879	E3 ligase Ligand 8		Others , Ligand for E3 Ligase
	E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoti...		Others , Ligand for E3 Ligase
T10765	Eragidomide	CC-90009,Cereblon modulator 1	Apoptosis , Ligand for E3 Ligase , Molecular Glues
	Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.		Apoptosis , Ligand for E3 Ligase , Molecular Glues
T5821	BC-1215		Others , Ligand for E3 Ligase
	BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).		Others , Ligand for E3 Ligase

Compounds

E3 ligase Ligand 23

T9809

Synonym:

Target: Ligand for E3 Ligase

SMER3

T23371

Synonym: SMER 3

Target: Others, Ligand for E3 Ligase

BC-1382

T8564

Synonym:

Target: Others, E1/E2/E3 Enzyme

Heclin

T24136

Synonym:

Target: E1/E2/E3 Enzyme

Lenalidomide-Br

T18064

Synonym:

Target: Ligand for E3 Ligase

Avadomide

T3549

Synonym: CC 122

Target: Apoptosis, E1/E2/E3 Enzyme, Ligand for E3 Ligase

ML-792

T16102

Synonym:

Target: E1/E2/E3 Enzyme

COH000

T5199

Synonym:

Target: E1/E2/E3 Enzyme

PYZD-4409

T16699

Synonym:

Target: Others, E1/E2/E3 Enzyme

NSC232003

T12261

Synonym:

Target: E1/E2/E3 Enzyme

SMIP004

T16901

Synonym:

Target: Apoptosis, Others, E1/E2/E3 Enzyme

NAcM-OPT

T5374

Synonym:

Target: E1/E2/E3 Enzyme, NEDD8

DKM 2-93

T7415

Synonym:

Target: E1/E2/E3 Enzyme

Nutlin-3

T2158

Synonym: Nutlin3

Target: E1/E2/E3 Enzyme

RO8994

T3517

Synonym:

Target: Mdm2, E1/E2/E3 Enzyme, p53

SJ-172550

T16888

Synonym:

Target: Mdm2, E1/E2/E3 Enzyme

Subasumstat

T8428

Synonym: TAK-981

Target: E1/E2/E3 Enzyme

2-D08

T7379

Synonym:

Target: E1/E2/E3 Enzyme, TAM Receptor

PYR-41

T6629

Synonym: PYR41,PYR 41

Target: Apoptosis, E1/E2/E3 Enzyme

MX69

T3653

Synonym:

Target: Mdm2, E1/E2/E3 Enzyme, IAP

YH239-EE

T6149

Synonym:

Target: Apoptosis, E1/E2/E3 Enzyme

WSB1 Degrader 1

T9236

Synonym:

Target: Others, E1/E2/E3 Enzyme

Ubiquitination-IN-1

Target: Apoptosis, Others, E1/E2/E3 Enzyme

MD-224

T11980

Synonym:

Target: Mdm2, E1/E2/E3 Enzyme, PROTACs

C25-140

T7889

Synonym:

Target: Others, TNF, E1/E2/E3 Enzyme, NF-κB

Mezigdomide

T10703

Synonym: CC-92480

Target: Apoptosis, E1/E2/E3 Enzyme, Molecular Glues

WS-383

T13349

Synonym:

Target: E1/E2/E3 Enzyme

Skp2 Inhibitor C1

T4253

Synonym: SKPin C1

Target: Others, E1/E2/E3 Enzyme

PRT4165

T3110

Synonym: NSC600157,PRT 4165

Target: BMI-1, Others, E1/E2/E3 Enzyme

Siremadlin

T5555

Synonym: NVP-HDM 201

Target: E1/E2/E3 Enzyme

Idasanutlin

T6254

Synonym: RG7388,Ro 5503781

Target: Mdm2, E1/E2/E3 Enzyme

RG7112

T6965

Synonym: RG-7112,RG 7112,RO5045337

Target: Mdm2, E1/E2/E3 Enzyme

TAK-243

T16974

Synonym: MLN7243

Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB

BH3I-1

T1493

Synonym: BHI1

Target: BCL, E1/E2/E3 Enzyme

NVP-CGM097

TQ0231

Synonym: CGM097

Target: Mdm2, E1/E2/E3 Enzyme

Navtemadlin

TQ0127

Synonym: AMG232,CS-1300

Target: Mdm2, E1/E2/E3 Enzyme

NSC697923

T6611

Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

Target: E1/E2/E3 Enzyme

Serdemetan

T2243

Synonym: JNJ-26854165

Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53

Nutlin-3a

T6023

Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3

Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy

GS143

T25465

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

SAR405838

T6585

Synonym: MI773,MI 773,MI-77301,MI-773

Target: Mdm2, E1/E2/E3 Enzyme

BC1618

T8929

Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK

Navitoclax-piperazine

T12186

Synonym: ABT-263-piperazine

Target: BCL, Ligands for Target Protein for PROTAC

Nutlin-3b

T6614

Synonym: (+)-Nutlin-3

Target: Mdm2, E1/E2/E3 Enzyme

dBRD9

T31221

Synonym: dBRD-9,dBRD 9

Target: PROTACs

NSC2805

T60078

Synonym: 2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol

Target: Others, Ligand for E3 Ligase

Eragidomide

T10765

Synonym: CC-90009,Cereblon modulator 1

Target: Apoptosis, Ligand for E3 Ligase, Molecular Glues

BC-1215

T5821

Synonym:

Target: Others, Ligand for E3 Ligase

カタログ番号	製品名	別名	ターゲット
T4S0181	Hinokiflavone		MMP , BCL , E1/E2/E3 Enzyme
	Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO...		MMP , BCL , E1/E2/E3 Enzyme
T9352	Hydrocotarnine		Others
	hydrocotarnine is an inhibitor of Cbl.		Others
T4036	Solasodine	Solancarpidine,Purapuridine,Solasodin	Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
	Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...		Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
T2947	Indole-3-carbinol	I3C,3-Indolemethanol,Indole-3-Methanol	E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53
	Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T6S2123	Ginkgolic Acid	Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),Ginkgolic acid C15:1	Others , E1/E2/E3 Enzyme
	Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.		Others , E1/E2/E3 Enzyme

天然物製品

Hinokiflavone

T4S0181

Synonym:

Target: MMP, BCL, E1/E2/E3 Enzyme

Synonym: Solancarpidine,Purapuridine,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Indole-3-carbinol

T2947

Synonym: I3C,3-Indolemethanol,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

Ginkgolic Acid

T6S2123

Synonym: Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),Ginkgolic acid C15:1

Target: Others, E1/E2/E3 Enzyme

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00361	Pellino-1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant ce...
TMPJ-01035	UBE2G2 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 10...
TMPJ-01053	UBE2I Protein, Human, Recombinant (GST)	Human	E. coli
	SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin ho...
TMPJ-01047	UBE2H Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived protei...
TMPJ-01198	UBE2R2 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex...
TMPJ-01403	UBE2D4 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational...
TMPK-01001	RNF43 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 i...
TMPJ-00985	UBE2A Protein, Human, Recombinant (GST, His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot...
TMPJ-00033	UBE2B Protein, Human, Recombinant (His)	Human	Human Cells
	Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPJ-01138	UBE2S Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activat...
TMPJ-00571	UBE2D3 Protein, Human, Recombinant	Human	E. coli
	UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubi...
TMPJ-01334	UBE2Z Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. ...
TMPJ-01039	UBE2K Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum...
TMPY-01654	ITCH Protein, Human, Recombinant (aa 526-903)	Human	E. coli
	E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ub...
TMPJ-01038	UBE2K Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum...
TMPY-02950	WWP2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thio...
TMPY-03510	Cbl-c Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, C...
TMPJ-00999	UBE2D1 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc)	Human	HEK293
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01259	AMFR Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPY-06026	VHL Protein, Human, Recombinant (His & Avi)	Human	E. coli
	VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli with His and AVI tag. The predicted molecular weight is 27.5 kDa. Accession number: A0A024R2F2
TMPJ-01386	STUB1 Protein, Human, Recombinant	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its ...
TMPY-01216	XIAP Protein, Human, Recombinant (Avi)	Human	E. coli
	E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor pr...
TMPY-02922	XIAP Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor pr...
TMPY-04153	RNF43 Protein, Human, Recombinant (His)	Human	HEK293
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPY-03441	SAE1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	SAE1 belongs to the ubiquitin-activating E1 family. It is a heterodimer that acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It functions as a UBLI E1 ligase mediating the ATP-dependent activation of UBL...
TMPJ-00717	BAG2 Protein, Human, Recombinant (His)	Human	E. coli
	BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is...
TMPY-01053	Prolactin Receptor Protein, Human, Recombinant (His)	Human	HEK293
	Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective recept...
TMPY-04413	IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04753	IRE1 Protein, Human, Recombinant (aa 465-977)	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-02101	KEAP1 Protein, Human, Recombinant (His & GST & Avi)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-01697	TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFR...
TMPY-03888	KEAP1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03235	BST2 Protein, Human, Recombinant (His)	Human	HEK293
	BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons...
TMPY-03432	KEAP1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-01166	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His)	Human	HEK293
	Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFR...
TMPY-03101	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
	Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFR...
TMPY-02521	HIST3H2A Protein, Human, Recombinant	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPH-01326	FBXO44 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
TMPH-01204	DCAF4 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
TMPH-03074	UBC5A Protein, Japonica rice, Recombinant (His & Myc)	Rice	E. coli
	E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins.
TMPH-03526	Cap8A Protein, S. aureus, Recombinant (His)	Staphylococcus aureus	in vitro E. coli expression system
	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate comp...
TMPH-02136	SPSB1 Protein, Human, Recombinant (His)	Human	E. coli
	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Nega...
TMPH-01657	MAGEA3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubi...
TMPH-01203	DCAF16 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.
TMPJ-01133	NEDD8 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recrui...
TMPH-01265	PELI3 Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPJ-01132	NEDD8 Protein, Human, Recombinant	Human	E. coli
	Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recrui...
TMPH-02651	Fbxo3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and ...
TMPJ-00441	CDH1 Protein, Human, Recombinant (His)	Human	Human Cells
	Cdh1 is one of the substrate adaptor protein of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae. Functioning as an activator of the APC/C, Cdh1 regulates the activity and substrate spec...
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